C-type Lectin-like Receptors (CTLRs)

C-type Lectin-like Receptors (CTLRs) are a class of protein receptors that contain a C-type lectin-like domain but do not necessarily rely on calcium ions to recognize ligands. They are usually classified as activating or inhibitory receptors, based on their intracellular signaling motifs. CTLRs are capable of recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), and play important roles in innate and adaptive immunity. After binding to ligands, CLRs act as antigen-uptake receptors, internalize antigens and present them to T cells, and activate multiple signaling pathways such as NF-κB, IFN, and inflammasomes to regulate the functions of immune cells. Abnormal expression or function of CLRs is closely related to cancer, infectious diseases, autoimmune diseases, and others^[1]^[2].

References:

[1]. Bartel Y, et al. Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human natural killer gene complex. Front Immunol. 2013 Nov 7;4:362.

[2]. Drouin M, et al. C-Type Lectin-Like Receptors: Head or Tail in Cell Death Immunity. Front Immunol. 2020 Feb 18;11:251. [Content Brief]

C-type Lectin-like Receptors (CTLRs) Related Products (47):

By Effects:	Inhibitors (28) Agonists (2) Ligand (1) Activators (4) Modulator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-131166

Curdlan	Activator	98.5%
Curdlan is a polysaccharide found in bacteria, consisting of a glucose homopolymer with β-1,3-glycosidic linkages. Curdlan can be recognized by Dectin-1 (a C-type lectin receptor), inducing immune responses in tissue mast cells and enhancing dendritic cell effects in tumor immunity. Curdlan holds potential for research in cancer and immune-inflammatory diseases.

HY-P9990

Litifilimab	Inhibitor	99.51%
Litifilimab (BIIB059) is a humanized anti-BDCA2 IgG1 monoclonal antibody administered subcutaneously. Litifilimab can inhibit the production of type I interferons, cytokines and chemokines. Litifilimab can be used in the research of diseases such as systemic lupus erythematosus.

HY-P990026

Ulviprubart	Modulator	99.39%
Ulviprubart (ABC-008) is a monoclonal antibody targeting the KLRG1 receptor that selectively depletes highly differentiated cytotoxic T cells. Ulviprubart can be used in the study of inclusion body myositis (IBM).

HY-P99389

Tesnatilimab		99.80%
Tesnatilimab (JNJ-64304500) is a human IgG4 monoclonal antibody targeting NKG2D, with a K_D value of 9.2 pM. Tesnatilimab blocks the binding of ligands to the NKG2D receptor, thereby inhibiting downstream proinflammatory cytokine, cytotoxic mediator signaling pathways and proinflammatory immune responses. Tesnatilimab is applicable to research related to Crohn's disease.

HY-N0434

Astragaloside III	Activator	99.70%
Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces TACE phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer.

HY-P991818

Anti-Mouse CD370 Antibody (1F6)	Inhibitor
Anti-Mouse CD370 Antibody (1F6) reacts with the mouse CD370 (also known as CLEC9A or DNGR1). CD370 is a type II membrane protein with a single extracellular C-type lectin domain. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979).

HY-P992391

IPH4301	Inhibitor
IPH4301 is a monoclonal antibody targeting MICA/B, with dual activities of cytotoxicity and immunoregulation. IPH4301 blocks the interaction between MICA/B and NKG2D, inhibits their hydrolysis into soluble sMICA/B, and mediates antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis against tumor cells expressing MICA/MICB. IPH4301 restores the expression and function of NKG2D on primary NK cells and T cells, reverses the immunosuppression induced by M2 macrophages, and enhances NK cell-mediated tumor cell apoptosis. IPH4301 can be used in research related to cancer and triple-negative breast cancer.

HY-P992163

23ME-01473	Activator
23ME-01473 is an anti-ULBP6/2/5 antibody with enhanced Fc effector function, with a K_d of 0.053 nmol/L against hULBP6, 0.23 nmol/L against hULBP2, and 1.92 nmol/L against hULBP5. 23ME-01473 restores anti-tumor immunity by activating NKG2D and FcγRIIIa. 23ME-01473 exerts anti-cancer activity in non-small cell lung cancer PDX models. 23ME-01473 can be used for the research of non-small cell lung cancer.

HY-P990178

Anti-Mouse NKG2D/CD314 Antibody (CX5)
Anti-Mouse NKG2D/CD314 Antibody (CX5) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse NKG2D/CD314. Anti-Mouse NKG2D/CD314 Antibody (CX5) reduces cytotoxicity of natural killer cells. Anti-Mouse NKG2D/CD314 Antibody (CX5) can be used for the researches of cancer, infection, inflammation, immunology and metabolic disease, such as colitis and diabetes.

HY-155311

NKG2D-IN-1	Inhibitor	99.84%
NKG2D-IN-1 (compound 21) is a natural killer group 2D receptor (NKG2D) inhibitor. NKG2D-IN-1 inhibits the protein-protein interaction between NKG2D and its ligands MICA and ULBP6, with IC₅₀ values of 0.3 μM and 0.7 μM. NKG2D-IN-1 can be used in the research of autoimmune diseases.

HY-P990284

Anti-Mouse CD205 Antibody (NLDC-145)
Anti-Mouse CD205 Antibody (NLDC-145) is a rat-derived IgG2aκ type antibody inhibitor, targeting to mouse CD205. Anti-Mouse CD205 Antibody (NLDC-145) reacts with CD205 also known as DEC-205. Anti-Mouse CD205 Antibody (NLDC-145) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as colitis, D2F2/E2 tumor and diabetes.

HY-P990258

Anti-Mouse CLEC9A/CD370 Antibody (7H11)	Inhibitor
Anti-Mouse CLEC9A/CD370 Antibody (7H11) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse CLEC9A/CD370. Anti-Mouse CLEC9A/CD370 Antibody (7H11) reacts with mouse CLEC9A (C-type lectin domain family member 9A) and blocks CLEC9A. Anti-Mouse CLEC9A/CD370 Antibody (7H11) can be used for the researches of cancer and immunology, such as B16.F10-OVA tumor.

HY-P990180

Anti-Mouse NKG2A/C/E Antibody (20D5)	Inhibitor
Anti-Mouse NKG2A/C/E Antibody (20D5) is an anti-mouse NKG2A/C/E IgG2a monoclonal antibody. Anti-Mouse NKG2A/C/E Antibody (20D5) can activate natural killer (NK) and CD8⁺ T cells. Anti-Mouse NKG2A/C/E Antibody (20D5) can exacerbate liver pathological damage by enhancing the activation of iNKT cells. Anti-Mouse NKG2A/C/E Antibody (20D5) can be used for researches on cancer and immunology such as lymphoma.

HY-W159303

7-Hydroxy-2,2-dimethyl-4-chromanone	Inhibitor
7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC₅₀ of 4.66 mM. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells.

HY-P991453

Anti-CD371/CLEC12A Antibody (H6e7)	Inhibitor
Anti-CD371/CLEC12A Antibody (H6e7) is a human monoclonal antibody (mAb) targeting CD371/CLEC12A. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99122

Anti-Mouse CD209b Antibody (22D1)	Inhibitor	99.00%
Anti-Mouse CD209b Antibody (22D1) is an anti-mouse CD209b IgG1 antibody inhibitor derived from the host Armenian Hamster. Anti-Mouse CD209b Antibody (22D1) can block SIGN-R1. Anti-Mouse CD209b Antibody (22D1) can be used for the researches of infection, inflammation and immunology, such as toxoplasma infection and pneumonia.

HY-155312

NKG2D-IN-2	Inhibitor
NKG2D-IN-2 (compound 47) is a natural killer group 2D receptor (NKG2D) inhibitor with IC₅₀s of 0.1 µM and 0.2 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively.

HY-P990205

Anti-Mouse/Human KLRG-1 Antibody (2F1)	Inhibitor
Anti-Mouse/Human KLRG-1 Antibody (2F1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse/human KLRG-1. Anti-Mouse/Human KLRG-1 Antibody (2F1) neutralizes KLRG1. Anti-Mouse/Human KLRG-1 Antibody (2F1) reduces T-cell receptor signals and regulatory T-cell accumulation. Anti-Mouse/Human KLRG-1 Antibody (2F1) can be used for the researches of immunology.

HY-173247

GalNAc-NAG37 phosphoramidite	Ligand	98.0%
GalNAc-NAG37 phosphoramidite is an N-acetylgalactosamine (GalNAc) derivative that acts as a ligand for the asialoglycoprotein receptor (ASGPR). GalNAc-NAG37 phosphoramidite can be used to synthesize GalNAc-siRNA and for oligonucleotide delivery.

HY-N15934A

(R)-MMG-1	Agonist
(R)-MMG-1 is the R-enantiomer of MMG-1. MMG-1, a monomycoloyl glycerol, is a C-type lectin receptor agonist. MMG-1, a lipid membrane stabilizer, is an immunopotentiator in liposomes. MMG-1 can be used to prepare lipid nanoparticles for drug delivery.

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